IN-VIVO SKIN QUANTIFICATION

AI-Assisted LC-OCT for Skin Analysis Beyond the Surface 

In a field where cosmetic and nutraceutical innovation demands rigor and transparency, Line-field Confocal Optical Coherence Tomography is the digital biopsy that goes beyond surface-level analysis - delivering real-time, non-invasive 3D imaging of the skin, to cellular-level detail down to the superficial dermis. 

Whether for running benchmarking studies, proof-of-concept trials, or exploring product's mechanism of action, LC-OCT - enhanced by AI-powered analysis - delivers sharper clinical insight and a deeper understanding of skin health and aging, to build more effective cosmetic and skincare strategies.

Crédit Quentin Mer

AVAILABLE BIOMARKERS
Skin Biomarker Quantification Using AI

 Support your claims with objective visual data, precisely characterize your active ingredients and the skin's condition, and demonstrate the true effectiveness of your formulations or dietary supplements 

Skin Layers & DEJ

Skin Layers & DEJ
Stratum corneum, epidermis thickness and undulation of DEJ

Keratinocyte Nuclei

Keratinocyte Nuclei
Density, compactness, volume, cellular network heterogeneity, number of layers

Melanin

Melanin
Surfacic and volumic melanin density at the basal layer and in the suprabasal layers

Fibers

Dermal Fibers
Fiber's density and orientation 


PARTNERSHIPS
How to work with us

Damae Medical supports you at every stage of your clinical studies using deepLive™, our non-invasive LC-OCT imaging device.

STEP 1 
Protocol Definition

 We support you in defining the best LC-OCT protocol based on our expertise. 

LC-OCT Probe

STEP 2 
Image Acquisition 

Carried out either through a CRO partner or directly by your own trained team.

STEP 3 
Analysis by Damae

Our imaging experts carefully analyze all the acquired image data.

STEP 4
Results & Delivery

We support you in interpreting data, writing your paper and creating tailored visuals.

SEE IT IN ACTION
The deepLive™ Acquisition Workflow 

COLOCALIZED DERMOSCOPE
It captures wide-field surface images, mapping the skin and acting as your GPS for precise colocalization with LC-OCT probe.

LC-OCT PROBE
It delivers cellular-resolution imaging (in vertical and horizontal format) for 3D digital biopsies.

AI-POWERED ANALYSIS
Enables in vivo quantification of skin microstructures and high-impact 3D visualizations.

EXAMPLE OF APPLICATION
LC-OCT-Based Skin Aging Biomarkers


Skin layer characterization in a cohort of 100 healthy Caucasian women aged 20–70.

Quantifying Skin Aging In Vivo

Stratum corneum thickness
Significant increase at the temples (+8%)  and mandible (+6%)

Epidermis thickness
Significant decrease at the mandible (-13%)

DEJ undulation
No significant change observed

F. Bonnier et al., LC-OCT coupled with AI algorithms to identify quantitative biomarkers of facial skin ageing, Scientific Reports, août 2023, doi:10.1038/s41598-023-40340-0

Our CRO Partners

TO GO FURTHER
Published and Peer-Reviewed

 Two resources to explore the science behind deepLive™'s AI-powered biomarkers. 

LC-OCT Dermocosmetic Booklet

PUBLICATIONS
Dermocosmetic
Booklet

 Discover the LC-OCT features as well as a collection of 15 studies selected from more than 300 publications, highlighting major advances accross clinical indications using LC-OCT. 

White Paper AI-Powered LC-OCT Biomarkers

WHITEPAPER
AI-Powered
LC-OCT Biomarkers

 Discover how the CE-marked deepLive™ generates digital skin features that act as objective biomarkers across inflammatory and oncologic dermatology. 

Frequently Asked Questions

 

Technology 

What are the key technology features

Cellular resolution (1 micron), allowing 3D visualization of skin structures.  An image acquisition takes usually less than 30 seconds. 

What is colocalized dermoscopy?

Colocalized dermoscopy is the newest addition to deepLive™: a fully integrated video dermatoscope for in vivo observation of fine skin features, colocalized with LC-OCT images. The hand-held dermoscope captures wide-field and color surface images improving imaging precision and streamlining your acquisition workflow - while allowing precise follow-up of the exact same area over time. 

Can we acquire a deepLive?

Yes - both rental and purchase options are available. You can contact us directly here for more information.

Biomarkers

Are there any other analysis available?

Beyond our validated biomarkers - Skin Layers & DEJ, Keratinocyte Nuclei, Melanin and dermal fibers - we're expanding our biomarker library:

Coming soon: New parameters on dermal Fibers, microvascularization

What are the deliverables?
Several options are available, ranging from raw data to a detailed statistical report including visuals. Deliverables typically include the quantitative results, along with an explanatory deck detailing the methodology and interpretation of the metrics. 
How are the algorithms developed?

Our AI models are trained on a database of more than 4,000 images spanning a broad diversity of skin types (healthy and pathological), ages (children to adults), sexes, and anatomical areas. Histology is used as the gold standard for validation. 

Working with us

Can Damae take care of the image acquisition?

No - acquisition is carried out by the client or their CRO partner. Damae provides the training and protocol support to ensure high-quality acquisitions. 

Is it possible to perform the analysis ourselves?

We offer AI based analysis carried out by Damae's clinical team to ensure consistency and reliability of the results. 

How is the price calculated?

Pricing depends on three main factors: the number of images to be analyzed, the biomarkers selected, and the type of deliverable chosen. 

MEET US 
Our Next Congress and Events

EADV 2026

Booth X2040

30 Sept. - 03 Oct.
Vienna

JDP 2026

Booth n°10

02 Dec. - 05 Dec.
Paris

EADO 2027

TBD

15 Apr. - 17 Apr.
Vienna

DDG 2027

TBD

21 Apr. - 24 Apr.
Berlin

GET IN TOUCH
 We are happy to support you in this new challenge. Please do not hesitate to give us your feedback and share with us your cases. 

deepLive™ is a CE-marked Class IIa medical device according to European Regulation 2017/745. Manufactured in France and distributed by Damae Medical. Examinations performed with deepLive™ must be carried out exclusively by a healthcare professional experienced in dealing with the diagnosis and management of dermatologic pathologies, in conjunction with the totality of relevant clinical information about the patient. It is not for use as a standalone diagnostic. Users are strongly advised to refer to the user manual and the device labeling to ensure proper and safe use.